Anti-Aging

Overview

Anti-aging peptide therapy targets the hallmarks of aging: telomere shortening, mitochondrial dysfunction, cellular senescence, hormonal decline, immune senescence, and declining proteostasis. A comprehensive approach combines epigenetic regulators, mitochondrial support peptides, GH axis optimization, and immune restoration. This is the most complex and individualized category in peptide therapy.

Recommended Peptides

Epitalon – tetrapeptide that activates telomerase; the only known peptide to directly lengthen telomeres; also restores melatonin production and circadian regulation
GHK-Cu – copper tripeptide with over 4,000 gene expression changes identified; resets fibroblasts to a younger phenotype and reduces inflammatory gene expression
MOTS-C – mitochondrial-derived peptide that improves metabolic flexibility and reduces age-related metabolic decline
SS-31 – cardiolipin-targeted mitochondrial protective peptide; reduces oxidative stress and restores mitochondrial membrane potential
NAD+ – precursor and/or direct supplementation to restore NAD+/NADH ratios that decline with age; activates sirtuins
Thymosin Alpha-1 – restores thymic function and T-cell competence; addresses immune senescence
FOXO4-DRI – senolytics peptide that induces apoptosis in senescent cells by disrupting FOXO4-p53 interaction
GDF-11 – growth differentiation factor linked to reversal of cardiac and skeletal muscle aging in parabiosis studies
Humanin – mitochondrial-derived peptide with neuroprotective and cytoprotective effects; declines significantly with age
CJC-1295 / Ipamorelin – GHRH/GHRP combination to restore youthful GH pulsatility; addresses GH axis decline
Tesamorelin – GHRH analogue with clinical approval; reduces visceral adiposity and improves metabolic markers of aging

Protocols

Related Conditions

Research Summary

MOTS-C reversed age-dependent physical decline in aged mice and is exercise-regulated in human skeletal muscle (PMID-33473109). Epitalon induced telomerase activation and telomere elongation in human fibroblasts (PMID-15455129) — though >90% of evidence comes from the Khavinson group. NAD+ supplementation via NMN increased muscle insulin sensitivity in prediabetic women (PMID-33888596). GHK-Cu modulates 4,000+ genes toward healthier expression patterns (PMID-25302294). Teriparatide (PTH 1-34) is the only FDA-approved anabolic bone agent for osteoporosis prevention in aging.

#condition #longevity