Thymulin
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Quick Facts
- Full Name: Thymulin (Facteur Thymique Sérique, FTS)
- Aliases: FTS, Serum Thymic Factor, Thymulin zinc complex
- Category: Immune Health / Thymic Peptides / Autoimmune / Anti-Inflammatory
- Sequence: pyroGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn (nonapeptide, zinc-dependent)
- Molecular Weight: 857.9 Da (zinc-bound active form: Zn²⁺ complexed)
- Administration: Subcutaneous / Intranasal
- Typical Dose: 5–20 mcg/day (microgram range — highly potent)
- Half-Life: Short; zinc-dependent activity
- Status: Research Only
- WADA Status: Not currently listed
What It Does
Thymulin is a naturally produced thymic nonapeptide that requires zinc for biological activity. It is the most thymus-specific of the thymic peptides — produced exclusively by thymic epithelial cells and levels decline dramatically with age and thymic involution. Thymulin promotes T-cell differentiation, maturation, and function; regulates T-helper/T-suppressor balance; and possesses anti-inflammatory and analgesic properties via neuroimmune pathways. Restoring thymulin levels in aged or immunocompromised individuals may partially reverse immunosenescence.
Mechanism of Action
- T-cell differentiation: Promotes differentiation of pre-T cells to mature functional T-lymphocytes in the thymus
- Zinc-dependent activation: Active only when complexed with Zn²⁺; zinc deficiency impairs thymulin activity (explains overlap between zinc deficiency and immune dysfunction)
- Th1/Th2 balance regulation: Modulates T-helper cell subtype ratios → improves immune tolerance and appropriate inflammatory responses
- NK cell enhancement: Stimulates natural killer cell activity → cancer immunosurveillance
- Anti-inflammatory signaling: Reduces TNF-α and IL-6; promotes IL-10 → resolution of chronic inflammation
- Analgesic effects: Neuroimmune modulation reduces inflammatory pain via hypothalamic-pituitary-adrenal pathway modulation
Ageless Peps Products
- AP-Thymalin-Vial — Thymalin (Thymulin) Vial, $48, retail (draft status)
Dosing Protocols
Standard Protocol
- Dose: 5–20 mcg SubQ daily (microgram doses — handle carefully)
- Frequency: Daily or 5 days on / 2 days off
- Duration: 10–14 day cycles (traditional thymic peptide approach) or 4–6 weeks
- Zinc co-administration: Ensure adequate zinc (15–30 mg/day elemental zinc) for maximum activity
- Source: The Peptides Bible, Peptide Protocols Master Bible
Stacks Well With
- Thymomodulin – complementary thymic fraction for broad thymic support
- Thymopentin – T-cell differentiation synergy (TP-5 acts on similar pathways)
- Thymosin Alpha-1 – combined thymic immune restoration stack
- VIP – immune modulation and anti-inflammatory complement
- LL-37 – innate + adaptive immune coverage
Use Cases
- Immune Restoration (immunosenescence, post-chemotherapy immune depletion)
- Autoimmune modulation (Th1/Th2 rebalancing)
- Chronic Infection (immune enhancement)
- Cancer Immunosurveillance (NK cell support)
- Anti-Aging (thymic restoration)
- Inflammatory Pain management
- Zinc Deficiency states (synergistic with zinc repletion)
Contraindications & Safety
- Active autoimmune conditions — T-cell stimulation may worsen; proceed with caution
- Post-organ transplant — immunosuppression regimens; avoid
- Active malignancy — NK cell / immune stimulation; discuss with oncologist
- Common side effects: Minimal at therapeutic doses; injection site reaction; very well tolerated
Storage
- Lyophilized: -20°C long-term; 2–8°C short-term
- Reconstituted: 2–8°C for 1–2 weeks; protect from light
- Solvent: Sterile/bacteriostatic water; handle gently
PubMed Research
Research links will be added after PubMed search
Sources
- The Peptides Bible – Thymic peptides section
- Peptide Protocols Master Bible – Immune restoration protocols
- Bach et al. — foundational thymulin and thymic peptide research
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