Thymopentin

Quick Facts

• Full Name: Thymopentin (TP-5)
• Aliases: TP-5, Thymopentine, Timunox
• Category: Immune Health / Thymic Peptides / T-Cell Modulation
• Sequence: Arg-Lys-Asp-Val-Tyr (5 amino acids — pentapeptide)
• Molecular Weight: 679.8 Da
• Administration: Subcutaneous / Intravenous
• Typical Dose: 50 mg SubQ 3x/week (clinical); research doses variable
• Half-Life: ~30 minutes
• Status: Approved in some countries (Italy, China); Research Only in USA
• WADA Status: Not listed

What It Does

Thymopentin (TP-5) is a synthetic pentapeptide corresponding to amino acids 32–36 of thymopoietin — the thymic hormone responsible for T-cell differentiation. It is the active core sequence of thymopoietin, possessing the full T-cell modulatory activity of the parent hormone in a five-amino-acid fragment. TP-5 promotes T-lymphocyte maturation, enhances CD4+/CD8+ T-cell ratios, restores immune defects in immunocompromised states, and has been used clinically for HIV, cancer immune support, and chronic infections.

Mechanism of Action

1. T-cell differentiation: Promotes differentiation of immature thymocytes into functional T-lymphocytes; mirrors thymopoietin full activity
2. CD4+ / CD8+ ratio normalization: Restores appropriate helper/suppressor T-cell balance in immune dysregulation
3. IL-2 and IFN-γ induction: Promotes secretion of Th1 cytokines → cellular immunity enhancement
4. NK cell activity: Enhances natural killer cell cytotoxic activity
5. B-cell regulation: Modulates B-cell activity through T-cell regulatory pathways → balanced humoral immunity
6. Cyclic AMP modulation: Acts via adenylyl cyclase → cAMP changes in T-lymphocyte precursors

Dosing Protocols

Clinical Protocol (Approved Countries)

• Dose: 50 mg SubQ
• Frequency: 3x per week
• Duration: 4–8 weeks; repeat as needed

Research / Immune Support Protocol

• Dose: 25–50 mg SubQ or IV
• Frequency: 2–3x per week
• Duration: 4–6 week cycles
• Cycling: 4 weeks on, 2–4 weeks off
• Source: The Peptides Bible, Peptide Protocols Master Bible

Stacks Well With

• Thymulin – complementary thymic peptide; zinc-dependent T-cell differentiation synergy
• Thymomodulin – broader thymic extract supporting TP-5 activity
• Thymosin Alpha-1 – combined thymic immunity stack (Zadaxin + TP-5 commonly combined)
• VIP – anti-inflammatory immune modulation
• LL-37 – innate immunity complement to TP-5 adaptive immunity effects

Use Cases

• Immune Restoration (primary and secondary immunodeficiency)
• HIV / AIDS support (immune reconstitution; historically used)
• Cancer Immunosupport (chemotherapy-induced immune depletion recovery)
• Autoimmune conditions (T-cell rebalancing)
• Chronic Infections (recurrent respiratory, viral infections)
• Anti-Aging (thymic T-cell function restoration)
• Allergy / Atopy (Th1/Th2 rebalancing)

Contraindications & Safety

• Post-organ transplant — T-cell stimulation opposes immunosuppression; avoid
• Active autoimmune flare — increased T-cell activity may worsen; caution
• Malignancy — discuss with oncologist; theoretical immune stimulation concerns
• Common side effects: Injection site reaction, mild fever (immune activation); well-tolerated overall
• Decades of clinical use in Italy and Asia; well-characterized safety profile

Storage

• Lyophilized: -20°C long-term; 2–8°C short-term (weeks)
• Reconstituted: 2–8°C for 1–2 weeks; protect from light
• Solvent: Sterile or bacteriostatic water

PubMed Research

Research links will be added after PubMed search

Sources

• The Peptides Bible – Thymic peptides section
• Peptide Protocols Master Bible – Immune protocols
• Goldstein et al. — thymopoietin/thymopentin foundational research

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