# M5.1 Lesson Package — README

**Lesson:** M5.1 Obesity Pathophysiology — Hormonal, Metabolic & Neural Drivers
**Module:** Synergy Health AI Academy — Module 5 (Weight Loss & Body Composition Management)
**Bundle version:** 2026-05-26
**Audience:** Licensed clinicians (MD / DO / NP / PA / PharmD within scope of practice). Patient-facing items are explicitly marked.

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## What's in this bundle

| # | File | Purpose | Audience |
|---|---|---|---|
| 00 | `00-M5.1-Lesson-Package-Index.pdf` | Bird's-eye tracker for the package | All |
| 01 | `01-Baseline-Labs-Checklist.pdf` | Thyroid / sex hormones / metabolic / inflammation panels | Clinician |
| 02 | `02-Phenotype-to-Peptide-Decision-Matrix.pdf` | Phenotype × peptide-class matrix with star ratings | Clinician |
| 03 | `03-Compounding-Pharmacy-Quality-Audit-Checklist.pdf` | USP 797/800, CoA, cold-chain, state licensure | Clinician |
| 04 | `04-Reconstitution-One-Pager.pdf` | Reconstitution + dose math + storage | Clinician + Patient |
| 05 | `05-Hormone-Optimization-Peptide-Reference-Card.pdf` | Sermorelin, CJC-1295/ipamorelin, kisspeptin-10, gonadorelin, BPC-157, thymosin alpha-1 | Clinician |
| 06 | `06-Informed-Consent-Template-Compounded-Peptide-Therapy.pdf` | Risks, benefits, alternatives, monitoring plan | Patient (signed) |
| 07 | `07-Patient-Handout-What-to-Expect-on-Semaglutide.pdf` | First 12 weeks, side effects, when to call | Patient |
| 08 | `08-Patient-Handout-Self-Injection-Technique.pdf` | Pen and vial-and-syringe walkthroughs | Patient |
| 09 | `09-Trial-Portfolio-Summary-Cards.pdf` | 20 landmark trial cards (STEP-1, SELECT, SURMOUNT-1/5, TRIUMPH-4, etc.) | Clinician + biohacker |
| 10 | `10-5-Safety-Fronts-Deep-Dive.pdf` | Cancer, pancreatitis, NAION, suicidality, pregnancy | Clinician |
| 11 | `11-M5.1-Knowledge-Check.pdf` | 15 case-based CME questions (passing 12/15) | All learners |
| 12 | `12-M5.1-Treatment-Initiation-Protocol.pdf` | Workflow doc sequencing Docs 1-11 into a clinical protocol | Clinician |

The video lesson (`M5.1-FINAL.mp4`, ~770 MB, 33:30) is separately downloadable from the academy site.

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## How to use this package

### As a clinician encountering this lesson for the first time

1. Watch the M5.1 video (33 min).
2. Read **Doc 12 — Treatment Initiation Protocol** to see how the other docs slot into a clinical workflow.
3. Skim **Doc 9 (trial cards)** + **Doc 10 (safety deep dive)** to anchor evidence.
4. Print **Doc 1 (labs)**, **Doc 6 (consent)**, **Doc 4 (reconstitution)** as your default-print stack for new initiations.
5. Hand patients **Docs 7 + 8** at the education visit.
6. Complete **Doc 11 (knowledge check)** for CME credit when you're ready.

### As Dr. Gross reviewing this package for clinical sign-off

See `M5.1-DR-GROSS-REVIEW-PACKET.md` (in the m5-content/M5.1/ folder) — that document brief covers:
- The audio change in the v10 narration (the B2 hormone framing rewrite)
- 4 critical docs needing your sign-off (Docs 2, 5, 10, 11)
- 6 docs where your input is recommended but non-blocking
- 1 doc needing separate legal review (Doc 6)

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## Version & status

- All 13 PDFs are **Draft v1** (2026-05-26).
- Documents needing Dr. Gross sign-off are flagged in the review packet.
- Doc 6 (Informed Consent) additionally requires legal review for state-specific compliance.
- Doc 12 (Treatment Initiation Protocol) is the workflow tying the others together.

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## Editorial standards

- Every clinical claim traces to a PubMed-indexed primary source (PMID) or regulatory document (FDA action, EMA classification).
- Pattern Z honesty discipline (present facts, name uncertainties, don't oversell/underscare).
- "Verify before use" flags inline wherever source material was thin.
- Pre-FDA-approval agents framed precisely per Pattern AA (no "leading," "promising," "emerging" qualifiers).

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## Contact

Editorial — Daria Pechaiko · Clinical authority — Dr. Jeffrey Gross MD

For questions, errata, or revision requests: contact the editorial team.
