PMID-36677050 – MOTS-c Functionally Prevents Metabolic Disorders
Gao Y et al. "MOTS-c Functionally Prevents Metabolic Disorders," Metabolites, 2023;13(1):125. doi:10.3390/metabo13010125
Quick Reference
| Property | Value |
|---|---|
| PMID | 36677050 |
| DOI | 10.3390/metabo13010125 |
| Year | 2023 |
| Journal | Metabolites |
| Study Type | Narrative Review |
| Evidence Level | V |
| Sample | Comprehensive review of MOTS-c metabolic literature |
| Peptide(s) Studied | MOTS-C |
Key Findings
- MOTS-c functions as a peptide hormone that reduces insulin resistance and prevents obesity
- Improves muscle function and promotes bone metabolism
- Enhances immune regulation and postpones aging
- Mechanisms: AMPK activation, folate cycle regulation, mitochondrial retrograde signaling
- Synthesizes evidence across metabolic, musculoskeletal, immune, and aging domains
Study Design
Comprehensive narrative review covering MOTS-c's roles across metabolic health. Synthesizes preclinical evidence from multiple organ systems and disease models.
Limitations
- Narrative review without systematic methodology
- Predominantly preclinical evidence reviewed
- Published in MDPI journal (variable review standards)
Clinical Relevance
Most comprehensive single-reference overview of MOTS-c's metabolic applications. Useful as a general reference for the MOTS-C peptide profile. The multi-system coverage supports MOTS-c's positioning in metabolic reset and anti-aging protocols.
Related
#research #narrative-review #evidence-level-V