PMID-28976144 – Immunoprotective Activity of Peptides in Spleen During Aging
Khavinson VKh, Linkova NS, Dyatlova AS. [Molecular aspects of immunoprotective activity of peptides in spleen during the ageing process]. Adv Gerontol. 2017;30(3):371-376.
Quick Reference
| Property | Value |
|---|---|
| PMID | 28976144 |
| DOI | — |
| Year | 2017 |
| Journal | Advances in Gerontology (Uspekhi Gerontologii) |
| Study Type | In vitro / Animal in vivo |
| Evidence Level | V |
| Sample | Aging rat spleen tissue and cell cultures |
| Peptide(s) Studied | Crystagen, Vilon |
Key Findings
- Crystagen (Glu-Asp-Pro) demonstrated immunoprotective effects in spleen tissue during aging
- Crystagen activated B-cells but had a greater effect on T-cell immunity (increased CD3+, CD4+ cells; normalized CD4+/CD8+ ratio)
- The peptide did not cause significant cell renewal in aged spleen but rather modulated existing immune cell function
- Vilon (Lys-Glu) showed complementary immunomodulatory activity
- The immunoprotective effect was attributed to peptide-mediated gene expression changes in immune cells
Study Design
Mixed in vitro/in vivo study examining the effects of short peptide bioregulators on spleen immune function during aging. Included both tissue culture experiments and assessment of splenic immune cell populations in aging rats.
Limitations
- Published in Russian-language journal (English abstract only)
- Limited description of methodology in English abstract
- All authors from the Khavinson group
- No independent replication
- The distinction between Crystagen's T-cell vs. B-cell effects needs independent confirmation
Clinical Relevance
Provides preclinical evidence for Crystagen's immune-supportive properties in aging. The T-cell predominant effect is relevant to age-related immunosenescence, but clinical validation is absent.
Methodological Note: This study originates from the Khavinson bioregulation group. Independent replication by Western laboratories is lacking.
Related
#research #animal-in-vivo #in-vitro #evidence-level-V #khavinson-bioregulator #peptide-crystagen