PMID-28212278 – GHK Gene Expression: Nervous System Function and Cognitive Decline
Pickart L, Vasquez-Soltero JM, Margolina A. "The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline," Brain Sciences, 2017;7(2):20. doi:10.3390/brainsci7020020
Quick Reference
| Property | Value |
|---|---|
| PMID | 28212278 |
| DOI | 10.3390/brainsci7020020 |
| Year | 2017 |
| Journal | Brain Sciences |
| Study Type | Narrative Review |
| Evidence Level | V |
| Sample | Gene expression analysis (Connectivity Map data) |
| Peptide(s) Studied | GHK-Cu |
Key Findings
- GHK modulates expression of genes relevant to Alzheimer's disease, Parkinson's disease, and cognitive decline
- Resets pathological neurological gene expression patterns toward healthier states
- Anti-oxidant, anti-inflammatory, and neuroprotective gene modulation identified
- Potential therapeutic relevance for age-related neurodegeneration
Study Design
Bioinformatic analysis of GHK's effects on neurological gene expression using the Broad Institute Connectivity Map. Focused on gene networks associated with neurodegenerative diseases and cognitive decline.
Limitations
- Computational analysis only; no animal or human neurological trial data
- Gene expression changes may not translate to functional neurological outcomes
- Same Pickart group and methodology as PMID-25302294
Clinical Relevance
Extends GHK's gene modulation evidence into the neurological domain. Relevant for the vault's cognitive enhancement and neuroprotection content. All conclusions remain theoretical — no in vivo neurological studies of GHK-Cu exist.
Related
#research #narrative-review #evidence-level-V