PMID-17947589 – Thymosin beta 4 induces hair growth via stem cell migration
Philp D et al. "Thymosin beta 4 induces hair growth via stem cell migration and differentiation," Annals of the New York Academy of Sciences, 2007;1112:95-103. doi:10.1196/annals.1415.009
Quick Reference
| Property | Value |
|---|---|
| PMID | 17947589 |
| DOI | 10.1196/annals.1415.009 |
| Year | 2007 |
| Journal | Annals of the New York Academy of Sciences |
| Study Type | Animal in vivo |
| Evidence Level | V |
| Sample | Rat and mouse hair growth models |
| Peptide(s) Studied | TB-500 |
Key Findings
- Tβ4 promotes hair growth in multiple rodent models
- Mechanism: stimulates hair follicle stem cell migration from the bulge region
- Increases stem cell differentiation and protease production in hair follicles
- Establishes a direct link between Tβ4's actin-binding/cell migration properties and hair follicle biology
Study Design
In vivo study using rat and mouse models. Tβ4 administered to assess effects on hair growth. Histological analysis of hair follicle morphology, stem cell markers, and migration assays.
Limitations
- Animal models only; human hair follicle biology differs
- Dose-response relationship not fully characterized
- Long-term effects on hair cycling not assessed
Clinical Relevance
Key primary study establishing Tβ4's hair growth promotion. Relevant for dermatological applications of TB-500 and potential inclusion in hair growth protocols. The stem cell migration mechanism connects to Tβ4's broader tissue repair biology.
Related
#research #animal-in-vivo #evidence-level-V