Post-Stroke Recovery Protocol
Overview
Stroke recovery with peptides is one of the most evidence-supported applications in the field. Semax is clinically approved in Russia specifically for ischemic stroke treatment. The acute phase (first 10-14 days post-stroke) is the critical window — interventions here have the greatest impact on limiting infarct expansion and initiating neuroplastic repair. The protocol has two distinct phases: acute (intensive, high-frequency dosing) and maintenance (continued neuroplastic support). Expected outcomes include reduced neurological deficit severity, faster functional recovery, improved cognitive outcomes, and better quality of life post-stroke compared to standard care alone.
Components — Acute Phase (Days 1-14)
| Peptide | Dose | Frequency | Duration |
|---|---|---|---|
| Semax 1% | 3-4 drops per nostril | 4-6x daily | 10-14 days |
| BPC-157 | 500 mcg SubQ | Daily | 10-14 days |
| Cerebrolysin | 10-30 mL IV (per physician) | Daily infusion | 10-21 days |
Components — Maintenance Phase (Weeks 2-12+)
| Peptide | Dose | Frequency | Duration |
|---|---|---|---|
| Semax 0.1% | 2-3 drops per nostril | 2-3x daily | 8-12 weeks |
| BPC-157 | 250-500 mcg SubQ | Daily | 8-12 weeks |
| TB-500 | 2.5 mg SubQ | 2x/week | 8-12 weeks |
| Cerebrolysin | 5-10 mL IV (per physician) | 2-3x/week | 8-12 weeks |
Administration
- Semax intranasal: Use 1% formulation in acute phase for maximum BDNF stimulation; dilute to 0.1% for maintenance; tilt head back slightly; apply to nasal mucosa and sniff gently; refrigerate
- BPC-157 SubQ: Abdominal injection; daily throughout; start as early as possible post-stroke
- Cerebrolysin: Requires IV administration — physician and clinical setting required; typical protocol is daily 10-30mL IV infusion in acute phase; confirmed safe in stroke meta-analyses; widely available in Europe and Asia
- TB-500: SubQ injection in maintenance phase; supports vascular repair in ischemic brain tissue
Cycling
- Acute phase: No cycling — continuous for 10-14 days
- Maintenance: 8-12 week course, then reassess functional recovery; additional courses can be administered with 4-week breaks
Expected Timeline
- Days 1-7: Reduction in neurological deficit progression; improved consciousness and alertness
- Days 7-14: Faster functional recovery vs standard care; measurable improvement on neurological scales
- Week 2-4: Language, motor, and cognitive rehabilitation accelerating
- Week 4-12: Continued neuroplastic remodeling; functional independence improving
- Beyond 12 weeks: Long-term neuroplastic changes; continued improvement possible with sustained protocol
Monitoring
- Neurological assessments: NIHSS (NIH Stroke Scale) at baseline, weekly in acute phase, monthly in maintenance
- MRI/CT imaging per standard post-stroke protocol
- Cognitive testing: MoCA (Montreal Cognitive Assessment) monthly
- Blood pressure monitoring — Semax may modulate blood pressure; daily BP tracking in acute phase
- Coordinate all peptide use with stroke neurology team
Contraindications
- Hemorrhagic stroke (different pathophysiology — most protocols are designed for ischemic stroke; consult neurologist)
- Active systemic infection or fever
- Allergy to porcine-derived products (Cerebrolysin is porcine-derived)
- Pregnancy
- Seizure disorder with recent uncontrolled events (Semax may lower seizure threshold in rare cases)
Sources
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