MK-677

⚠️ Structural Separation Notice

The Ageless Pep Academy is a clinical education property independent from any commerce operation. Any references in this profile to Ageless Peps product SKUs, pricing, or the agelesspeps.com domain are for completeness and transparency; they are not endorsements and do not form part of the clinical education content. Clinicians are responsible for independent verification of any product sourcing decision. The Academy's Medical Director provides editorial oversight only and does not endorse commercial products.

Quick Facts

Full Name: Ibutamoren Mesylate
Aliases: MK-677, L-163,191, Nutrobal
Category: GH Axis / Muscle / Fat Loss / Sleep
Type: Non-peptide oral GH secretagogue (ghrelin mimetic small molecule)
Molecular Weight: 624.8 Da
Administration: Oral
Typical Dose: 10–25 mg/day
Half-Life: ~24 hours (allows once-daily dosing)
Status: Research Only (not FDA-approved)
WADA Status: Prohibited (S2)

What It Does

MK-677 (Ibutamoren) is a non-peptide oral ghrelin mimetic that mimics the action of ghrelin to stimulate GH and IGF-1 secretion. Unlike injectable GH secretagogues, it is orally bioavailable and has a 24-hour half-life, enabling once-daily dosing. It significantly elevates GH and IGF-1 levels, improves body composition, enhances slow-wave sleep, and supports bone density — without suppressing endogenous GH production.

Mechanism of Action

GHS-R1a agonism (oral): Binds ghrelin receptor in pituitary and hypothalamus → sustained GH pulse amplitude increase throughout the day/night
24-hour half-life: Long half-life produces a more tonic GH elevation vs. pulsatile injection-based protocols
IGF-1 elevation: Sustained GH drives robust hepatic IGF-1 production — often 50–100% above baseline
Appetite stimulation: Ghrelin pathway activation increases hunger; manage with dietary discipline or GLP-1 support
Sleep architecture improvement: Increases slow-wave (delta) sleep duration and quality

Ageless Peps Products

AP-MK677-Capsules — MK-677 Capsules, $215, retail (draft status)

Dosing Protocols

Standard Protocol

Dose: 10–25 mg orally
Timing: Evening / bedtime (amplifies nocturnal GH pulse, manages daytime hunger)
Frequency: Once daily
Duration: 3–6 months; can be used continuously long-term at lower doses
Cycling: Optional 5 days on / 2 days off to manage appetite side effects
Source: The Peptides Bible, Peptides Made Easy

Conservative (Sleep/Anti-Aging) Protocol

Dose: 10 mg at bedtime
Goal: Sleep quality and GH restoration with minimal appetite disruption

Stacks Well With

PEG-MGF – GH axis + local muscle repair synergy
IGF-1 LR3 – additive anabolic effect downstream of GH axis
Ipamorelin – complementary pulsatile GHRP to MK-677's tonic GH elevation
CJC-1295 NO DAC – GHRH partner for maximal GH axis stimulation
Semaglutide – manages MK-677-driven appetite increase

Use Cases

GH Axis Optimization (GH deficiency, age-related GH decline)
Muscle Growth and lean mass accrual
Fat Loss via GH-mediated lipolysis
Sleep Quality and slow-wave sleep enhancement
Bone Density improvement
Recovery from training
Anti-Aging

Contraindications & Safety

Active malignancy — GH/IGF-1 elevation; avoid
Insulin resistance / T2DM — elevates blood glucose and fasting insulin; monitor HbA1c
Fluid retention — edema, carpal tunnel syndrome at higher doses
Prolactin elevation — mild; monitor
Long-term IGF-1 elevation — theoretical cancer risk at very high sustained levels
Common side effects: Hunger (especially first 1–2 weeks), water retention, fatigue (morning), mild insulin resistance

Storage

Oral capsules/liquid: Room temperature; away from heat, light, moisture
Stability: Highly stable as a small molecule; 1–2 year shelf life

PubMed Research

Research links will be added after PubMed search

Sources

The Peptides Bible – GH axis and oral secretagogues
Peptides Made Easy – Dosing protocols
Peptide Protocols Master Bible – Evidence-based guide

#GH-axis #muscle #fat-loss #sleep #anti-aging #oral #ibutamoren #MK677 #growth-hormone