Hexarelin

Quick Facts

Full Name: Hexarelin (Examorelin)
Aliases: EP-23905, MF-6003
Category: GH Axis / Cardioprotection / Recovery
Sequence: His-D-2MeTrp-Ala-Trp-D-Phe-Lys-NH2 (hexapeptide)
Molecular Weight: 887.1 Da
Administration: Subcutaneous / Intranasal
Typical Dose: 100–200 mcg per injection
Frequency: 2–3x daily
Half-Life: ~30–60 minutes
Status: Research Only
WADA Status: Prohibited (S2)

What It Does

Hexarelin is among the most potent synthetic GH secretagogues and uniquely possesses direct cardioprotective properties independent of its GH-releasing activity. It binds both GHS-R1a (ghrelin receptor) and CD36 scavenger receptors on cardiac tissue, conferring direct myocardial protection. This dual action makes it particularly valuable in cardiac rehabilitation and recovery contexts alongside its GH axis benefits.

Mechanism of Action

GHS-R1a agonism: Potent ghrelin receptor activation → strong GH pulse (among the highest of any GHRP)
CD36 receptor binding: Direct cardiac action — activates PI3K/Akt cardioprotective signaling independent of GH
Myocardial protection: Reduces ischemia-reperfusion injury, preserves cardiac function, anti-apoptotic effects on cardiomyocytes
Cortisol and prolactin elevation: More pronounced than other GHRPs; dose-dependent
Tachyphylaxis tendency: Faster desensitization than Ipamorelin or Sermorelin — cycling is important

Dosing Protocols

Standard Protocol

Dose: 100–200 mcg SubQ
Frequency: 2–3x daily
Timing: Fasted state for maximal GH pulse
Duration: 6–8 weeks; cycle off 4 weeks (tachyphylaxis risk)
Source: The Peptides Bible, Peptides Made Easy

Cardioprotective Protocol

Dose: 100 mcg SubQ once daily (cardiac context)
Duration: As directed; combine with TB-500 for tissue synergy

Stacks Well With

TB-500 – cardiac and tissue recovery synergy
PEG-MGF – muscle repair and GH axis amplification
BPC-157 – tissue healing complement
CJC-1295 NO DAC – GHRH pairing for supra-additive GH pulse

Use Cases

GH Axis Optimization
Cardioprotection (ischemic heart disease, post-cardiac event recovery)
Muscle Growth and body composition
Recovery from training or injury
Fat Loss via GH-mediated lipolysis

Contraindications & Safety

Active malignancy — GH stimulation; avoid
Cortisol-sensitive conditions — notable cortisol elevation vs. Ipamorelin
Prolactin-sensitive conditions — monitor prolactin
Tachyphylaxis — more rapid than other GHRPs; mandatory cycling
Common side effects: Fatigue, water retention, increased appetite (less than GHRP-6), cortisol/prolactin elevations
Not for continuous use — tachyphylaxis limits long protocols

Storage

Lyophilized: -20°C long-term; 2–8°C up to 3 months
Reconstituted: 2–8°C for 2–4 weeks; protect from light
Solvent: Bacteriostatic water preferred

PubMed Research

Research links will be added after PubMed search

Sources

The Peptides Bible – GH secretagogue protocols
Peptides Made Easy – Dosing and cycling
Peptide Protocols Master Bible – Evidence-based guide

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