Follistatin 344

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Quick Facts

• Full Name: Follistatin-344 (FST-344)
• Aliases: FST344, Follistatin isoform 344
• Category: Muscle Growth / Myostatin Inhibition / Body Composition
• Molecular Weight: ~35 kDa (glycoprotein)
• Administration: Subcutaneous / Intramuscular
• Typical Dose: 100 mcg/day
• Half-Life: ~3.5 hours
• Status: Research Only
• WADA Status: Prohibited (S0/S4)

What It Does

Follistatin-344 is an endogenous glycoprotein that acts as a potent myostatin inhibitor, removing the primary biological brake on skeletal muscle growth. By neutralizing myostatin (GDF-8) and activin, it enables muscle hypertrophy beyond natural limits. Used in short cycles due to profound anabolic effects and the importance of allowing myostatin to normalize. Represents one of the most powerful muscle-building interventions in the peptide space.

Mechanism of Action

1. Myostatin (GDF-8) binding and neutralization: Follistatin binds myostatin with high affinity → prevents myostatin from engaging ActRII receptors → removes inhibition on muscle satellite cell proliferation and differentiation
2. Activin A/B inhibition: Also neutralizes activins → additional anti-catabolic and pro-anabolic effects in muscle and reproductive tissues
3. Satellite cell activation: Removal of myostatin brake → dramatically increased muscle satellite cell proliferation → hypertrophy and potential hyperplasia
4. FSH suppression: Follistatin also suppresses FSH in the HPG axis — relevant consideration for fertility
5. ActRIIB pathway modulation: Complementary to ACE-031 and similar myostatin pathway agents

Ageless Peps Products

• APWS-FST344-Vial — Follistatin 344 1mg Vial, $85, wholesale only

Dosing Protocols

Standard Cycle Protocol

• Dose: 100 mcg SubQ or IM
• Frequency: Once daily
• Duration: 10–20 day cycles (short cycles due to potency)
• Rest period: 4–6 weeks between cycles
• Injection site: Localized injection near target muscle groups reportedly enhances local effect
• Source: The Peptides Bible, Peptides Made Easy

Stacks Well With

• Semaglutide – body recomposition: muscle gain + fat loss simultaneously
• GHRP-6 – GH axis amplification alongside myostatin inhibition
• MOD-GRF-1-29 + TB-500 – tissue regeneration and healing complement
• IGF-1 LR3 – downstream anabolic synergy

Use Cases

• Muscle Growth (advanced hypertrophy beyond natural limits)
• Body Recomposition
• Muscle Wasting conditions (cachexia, sarcopenia)
• Athletic Performance
• Injury Recovery (accelerated muscle rebuilding)

Contraindications & Safety

• Active malignancy — growth factor; avoid
• FSH-sensitive conditions — suppresses FSH; affects fertility in both sexes
• Ovarian hyperstimulation risk in women
• Long cycles — prolonged myostatin suppression may have unknown long-term consequences
• Organ/cardiac muscle — myostatin also regulates cardiac muscle; theoretical cardiac hypertrophy risk with abuse
• Common side effects: Localized muscle fullness/swelling, temporary FSH suppression, joint discomfort at high doses

Storage

• Lyophilized: -20°C long-term; 2–8°C up to 3 months
• Reconstituted: 2–8°C for 2–4 weeks; protect from light and agitation
• Solvent: Bacteriostatic water; handle gently (protein)

PubMed Research

Research links will be added after PubMed search

Sources

• The Peptides Bible – Myostatin inhibitor protocols
• Peptides Made Easy – Dosing and cycling
• Peptide Protocols Master Bible – Evidence-based guide

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