Metabolic Reset Protocol
Overview
The Metabolic Reset Protocol targets insulin resistance, mitochondrial dysfunction, impaired fat oxidation, and the downstream metabolic consequences of sedentary modern lifestyles. It combines the exercise-mimetic properties of MOTS-C, the NNMT-inhibiting fat-storage blockade of 5-Amino-1MQ, and the mitochondrial and sirtuin-activating power of NAD+. This protocol is particularly valuable for metabolic syndrome, pre-diabetes, sarcopenic obesity, and individuals who cannot exercise adequately due to injury or illness. Expected outcomes include improved insulin sensitivity, increased energy, better body composition, and normalization of key metabolic markers.
Components
| Peptide | Dose | Frequency | Duration |
|---|---|---|---|
| MOTS-C | 5-10 mg SubQ | 3x/week (Mon/Wed/Fri) | 4-8 weeks |
| 5-Amino-1MQ | 100 mg oral | Daily | 4-8 weeks |
| NAD+ | 100-200 mg SubQ | 2-3x/week | 4-8 weeks |
Administration
- MOTS-C: SubQ injection; pre-exercise if exercising (amplifies training adaptation); alternatively morning on non-exercise days; reconstitute in bacteriostatic water
- 5-Amino-1MQ: Oral capsule; can be taken with food; morning dosing to align with metabolic activity patterns; some users find it mildly stimulating — avoid late evening
- NAD+: SubQ injection preferred; some users experience a transient "flush" or energy surge — start at 50mg and titrate up; can be taken morning or midday
Cycling
- 4-8 week protocol then 4 weeks off
- Labs guide re-initiation: if metabolic markers have normalized, maintenance phase at reduced frequency (e.g., MOTS-C 1-2x/week, NAD+ once weekly)
- Some practitioners use year-round 5-Amino-1MQ at 50mg/day continuously
Expected Timeline
- Week 1-2: Increased energy and exercise tolerance; MOTS-C improving mitochondrial function
- Week 2-4: Improved fasting glucose and insulin sensitivity; fat oxidation increasing
- Week 4-6: Measurable body composition improvements; reduced visceral circumference
- Week 6-8: Normalization of metabolic markers; sustained improvement in energy metabolism
Monitoring
- Metabolic panel at baseline, week 4, and end of protocol: fasting glucose, insulin, HOMA-IR, HbA1c, lipid panel
- DEXA scan at baseline and 8 weeks (body composition)
- Track waist circumference weekly
- Energy and exercise performance diary
- Liver enzymes at baseline (NAD+ and 5-Amino-1MQ — hepatic metabolism)
Contraindications
- Active cancer (avoid MOTS-C and growth-promoting peptides)
- Severe hepatic impairment
- Pregnancy or breastfeeding
- Type 1 diabetes — requires careful glucose monitoring if combining with insulin therapy
Sources
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