Anti-Aging Daily Protocol
Overview
A comprehensive daily anti-aging protocol targeting the primary hallmarks of aging: telomere attrition (Epitalon), extracellular matrix decline and inflammatory gene expression (GHK-Cu), mitochondrial dysfunction and NAD+ depletion (NAD+), and metabolic decline (MOTS-C). This protocol is designed for long-term use with strategic cycling to maintain receptor sensitivity and prevent tolerance. Expected outcomes include improved energy, sleep quality, skin appearance, metabolic markers, and subjective sense of vitality.
Components
| Peptide | Dose | Frequency | Duration |
|---|---|---|---|
| Epitalon | 5-10 mg | Nightly (10-20 day cycle) | 2 cycles/year |
| GHK-Cu | Topical serum | Daily AM/PM | Ongoing |
| NAD+ | 100-200 mg SubQ | 2-3x/week | Ongoing |
| MOTS-C | 5 mg | 3x/week (e.g. Mon/Wed/Fri) | 4-8 weeks on, 4 weeks off |
Administration
- Epitalon: SubQ injection, nighttime (aligns with natural pineal activity); reconstitute in bacteriostatic water; 5mg/day for 10-20 days, then 2-3 month break
- GHK-Cu: Topical serum applied morning and evening to face, neck, and hands; no injection required for skin benefits; injectable GHK-Cu 1-2mg SubQ for systemic effects
- NAD+: SubQ injection preferred for superior bioavailability vs oral; can be done at any time but morning is conventional; some users experience a flushing or "energy surge" — start at low dose
- MOTS-C: SubQ injection; any time of day; some prefer pre-workout for exercise synergy
Cycling
- Epitalon: 10-20 day on / 2-3 month off / repeat 2x per year (spring and fall common)
- NAD+: Can be used continuously or cycled 4 weeks on/2 weeks off
- MOTS-C: 4-8 weeks on / 4 weeks off; or 3x weekly year-round at lower dose
- GHK-Cu topical: Daily continuous use; no tolerance concerns with topical
Expected Timeline
- Week 1-2: Improved sleep (Epitalon effect), increased energy (NAD+)
- Week 3-4: Improved skin texture and firmness (GHK-Cu); improved metabolic markers
- Month 2-3: Objective improvements in inflammatory markers, skin quality, and body composition
- 6+ months: Telomere preservation effects (Epitalon); cumulative skin remodeling; improved biological age markers
Monitoring
- Annual telomere length testing (e.g. TruDiagnostic) to track Epitalon impact
- Quarterly metabolic panel (glucose, lipids, insulin, CRP)
- Track sleep quality via wearable
- Skin quality photography at baseline and 3-month intervals
Contraindications
- Active cancer (all growth-promoting peptides contraindicated)
- Pregnancy or breastfeeding
- G6PD deficiency (NAD+ precursor caution)
- Consult physician before combining with hormone replacement therapy
Sources
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