PMID-36611900 – SASP of Cardiovascular System Cells and Inflammaging: Peptide Regulation
Khavinson VKh, Linkova NS, Umnov RS, Dyatlova AS. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. Cells. 2023;12(1):106.
Quick Reference
| Property | Value |
|---|---|
| PMID | 36611900 |
| DOI | 10.3390/cells12010106 |
| Year | 2023 |
| Journal | Cells |
| Study Type | Narrative Review |
| Evidence Level | V |
| Sample | Review of literature on cardiovascular aging and peptide bioregulators |
| Peptide(s) Studied | Cardiogen, Vilon |
Key Findings
- Vasoprotective polypeptides including the AEDR tetrapeptide (Cardiogen) regulate synthesis of molecules involved in inflammaging and SASP (senescence-associated secretory phenotype) in cardiovascular cells
- The KED tripeptide and AEDR tetrapeptide specifically modulate inflammatory pathways associated with vascular aging
- Review proposes that short peptide bioregulators may counteract age-related cardiovascular decline by reducing SASP-mediated chronic inflammation
- Integrates Cardiogen into the broader context of cardiovascular geroscience
Study Design
Narrative review examining the senescence-associated secretory phenotype in cardiovascular system cells and the role of chronic low-grade inflammation (inflammaging) in cardiovascular disease. Discusses potential of peptide bioregulators as interventions.
Limitations
- Narrative review, not a systematic review — selection bias in cited literature
- All authors from the Khavinson group
- Heavily draws on the group's own preclinical data
- No clinical trial evidence for Cardiogen in cardiovascular disease
- No independent replication of the proposed mechanisms
Clinical Relevance
Provides a theoretical framework for using Cardiogen in cardiovascular aging. The inflammaging concept is well-established in geroscience, but the specific role of Cardiogen in addressing it remains preclinical and unvalidated by independent groups.
Methodological Note: This review originates from the Khavinson bioregulation group. Independent replication by Western laboratories is lacking.
Related
#research #narrative-review #evidence-level-V #khavinson-bioregulator #peptide-cardiogen