PMID-34992578 – Progress on the Function and Application of Thymosin β4
Xing Y et al. "Progress on the Function and Application of Thymosin β4," Frontiers in Endocrinology, 2021;12:767785. doi:10.3389/fendo.2021.767785
Quick Reference
| Property | Value |
|---|---|
| PMID | 34992578 |
| DOI | 10.3389/fendo.2021.767785 |
| Year | 2021 |
| Journal | Frontiers in Endocrinology |
| Study Type | Narrative Review |
| Evidence Level | V |
| Sample | Comprehensive review of Tβ4 literature |
| Peptide(s) Studied | TB-500 |
Key Findings
- Tβ4 plays pivotal roles in angiogenesis, cell proliferation, apoptosis inhibition, and anti-inflammation
- Therapeutic potential in: myocardial infarction, ischemia-reperfusion injury, dry eye, liver/renal fibrosis, ulcerative colitis, skin trauma
- Operates through multiple signaling pathways: NF-κB, PI3K/Akt/eNOS, Notch, TGF-β, and Wnt
- Summarizes clinical development status as of 2021
Study Design
Comprehensive narrative review synthesizing Tβ4 biology and applications across multiple organ systems. Covers molecular mechanisms, preclinical evidence, and translational potential.
Limitations
- Narrative format without systematic methodology
- Predominantly preclinical evidence discussed
- Some claims based on early-stage or limited studies
Clinical Relevance
Provides a well-organized 2021 overview of the entire Tβ4 therapeutic landscape. The multi-pathway signaling discussion (NF-κB, PI3K/Akt/eNOS, Notch, TGF-β, Wnt) is particularly valuable for understanding TB-500's broad mechanisms. Good general reference for the TB-500 peptide profile.
Related
#research #narrative-review #evidence-level-V