PMID-28721271 – NAD+ and Sirtuins in Aging Control
Imai SI, Guarente L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016;2:16017.
Quick Reference
| Property | Value |
|---|---|
| PMID | 28721271 |
| DOI | 10.1038/npjamd.2016.17 |
| Year | 2016 |
| Journal | NPJ Aging Mech Dis |
| Study Type | Narrative Review |
| Evidence Level | V |
| Sample | N/A (review) |
| Peptide(s) Studied | NAD+ |
Key Findings
- Introduces and expands the "NAD World" concept, describing how the NAD+ biosynthesis and sirtuin axis are functionally coupled to regulate systemic aging
- Details the role of NAMPT as a rate-limiting NAD+ biosynthetic enzyme and NMN as the key systemic NAD+ intermediate
- Describes hypothalamic NAD+/SIRT1 regulation as a central aging control mechanism with downstream effects on peripheral tissues
Study Design
Seminal narrative review co-authored by Shin-ichiro Imai and Leonard Guarente, the two leading researchers in NAD+ biology and sirtuin signaling. Synthesizes evidence from genetic, biochemical, and physiological studies in model organisms and early human data to construct a unified framework for NAD+-sirtuin aging control.
Limitations
- As a narrative review, subject to author selection bias in evidence presentation
- Primarily based on preclinical data; human validation was limited at time of publication
Clinical Relevance
Provides the foundational theoretical framework underpinning NAD+ supplementation strategies for anti-aging, making it essential reading for understanding why NMN and NR are pursued as longevity interventions.
Related
#research #narrative-review #evidence-level-V