PMID-28370978 – GHK-Cu-Liposomes Accelerate Scald Wound Healing
Wang X et al. "GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis," Wound Repair and Regeneration, 2017;25(2):270-278. doi:10.1111/wrr.12520
Quick Reference
| Property | Value |
|---|---|
| PMID | 28370978 |
| DOI | 10.1111/wrr.12520 |
| Year | 2017 |
| Journal | Wound Repair and Regeneration |
| Study Type | Animal in vivo |
| Evidence Level | V |
| Sample | Mice with scald (burn) wounds |
| Peptide(s) Studied | GHK-Cu |
Key Findings
- GHK-Cu encapsulated in liposomes enhanced scald wound healing in mice
- Increased HUVEC proliferation rate by 33.1% vs. free GHK-Cu
- Shortened healing time to 14 days with enhanced angiogenesis markers
- Liposomal delivery improved GHK-Cu bioavailability at wound site
- Enhanced both cell proliferation and blood vessel formation
Study Design
Controlled animal study. Mice received scald (burn) wounds and were treated with GHK-Cu-liposomes, free GHK-Cu, or controls. Outcomes: wound closure rate, histology, angiogenesis markers, cell proliferation assays.
Limitations
- Mouse burn model; human burn healing differs
- Liposomal formulation may not reflect injectable GHK-Cu products
- Single wound type (scald); applicability to other wound types unknown
Clinical Relevance
Published in the priority journal Wound Repair and Regeneration. The liposomal delivery enhancement is relevant for formulation science. Demonstrates GHK-Cu's wound healing in a clinically relevant burn model. Supports the GLOW blend's wound healing rationale.
Related
#research #animal-in-vivo #evidence-level-V