PMID-18642713 – Pancragen Effects on Blood Glucose and Capillary Permeability in Experimental Diabetes
Khavinson VKh, Linkova NS, Trofimova SV. Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus. Bull Exp Biol Med. 2008;145(4):489-492.
Quick Reference
| Property | Value |
|---|---|
| PMID | 18642713 |
| DOI | 10.1007/s10517-008-0127-9 |
| Year | 2008 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Study Type | Animal in vivo |
| Evidence Level | V |
| Sample | Rats with streptozotocin-induced experimental diabetes mellitus |
| Peptide(s) Studied | Pancragen |
Key Findings
- Pancragen (Lys-Glu-Asp-Trp) reduced blood glucose levels in rats with experimental diabetes mellitus
- The peptide decreased pathological capillary permeability associated with diabetic microangiopathy
- Pancragen improved adhesion parameters, suggesting vascular endothelial protective effects
- Results suggest potential for Pancragen in addressing diabetic complications beyond glycemic control
Study Design
Animal study using streptozotocin-induced diabetes model in rats. Animals received Pancragen treatment and were assessed for blood glucose levels, capillary permeability, and adhesion markers compared to diabetic controls.
Limitations
- Chemical diabetes model (streptozotocin) does not fully replicate human type 2 diabetes
- Small sample size typical of Khavinson group animal studies
- No dose-response analysis reported
- All authors from the Khavinson group
- No independent replication
Clinical Relevance
Provides preclinical evidence that Pancragen may have glucose-lowering and vascular-protective effects in diabetes. However, the streptozotocin model primarily represents type 1 diabetes, and translation to human metabolic disease is speculative.
Methodological Note: This study originates from the Khavinson bioregulation group. Independent replication by Western laboratories is lacking.
Related
#research #animal-in-vivo #evidence-level-V #khavinson-bioregulator #peptide-pancragen