PMID-11087911 – Epitalon Lifespan Increase in Drosophila
Khavinson VKh, Izmailov DM, Obukhova LK, Malinin VV. Effect of Epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2000;120(1-3):141-149.
Quick Reference
| Property | Value |
|---|---|
| PMID | 11087911 |
| DOI | 10.1016/s0047-6374(00)00217-7 |
| Year | 2000 |
| Journal | Mechanisms of Ageing and Development |
| Study Type | Animal in vivo |
| Evidence Level | V |
| Sample | Drosophila melanogaster (multiple cohorts, both sexes) |
| Peptide(s) Studied | Epitalon |
Key Findings
- Epitalon increased mean lifespan of Drosophila melanogaster by 11-16% at low concentrations
- The lifespan extension effect was more potent than melatonin supplementation under similar conditions
- The effect was not dose-dependent; higher concentrations did not produce proportionally greater lifespan gains
Study Design
Drosophila melanogaster of both sexes were maintained under controlled laboratory conditions and treated with Epitalon at varying concentrations added to the culture medium. Lifespan was tracked and compared against untreated controls and melatonin-treated groups. Multiple cohorts were used to assess dose-response relationships.
Limitations
- Invertebrate model with limited translatability to mammalian or human aging biology
- Absence of a clear dose-response relationship complicates mechanistic interpretation
- Methodological note: Study originates from the Khavinson research group, which has produced the majority of published Epitalon research. Independent replication in Drosophila models has not been reported.
Clinical Relevance
The lifespan extension in an invertebrate model provides early-stage evidence supporting Epitalon's potential geroprotective properties. However, Drosophila biology differs substantially from mammalian systems, and these results cannot be directly extrapolated to human anti-aging applications without mammalian and ultimately clinical data.
Related
#research #animal-in-vivo #evidence-level-V