PMID-10944717 – Vilon Inhibits Spontaneous Tumors and Increases Lifespan in Mice
Anisimov VN, Khavinson VKh, Morozov VG. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits growth of spontaneous tumors and increases life span of mice. Mech Ageing Dev. 2000;116(2-3):89-98.
Quick Reference
| Property | Value |
|---|---|
| PMID | 10944717 |
| DOI | 10.1016/S0047-6374(00)00113-1 |
| Year | 2000 |
| Journal | Mechanisms of Ageing and Development |
| Study Type | Animal in vivo |
| Evidence Level | V |
| Sample | Female SHR mice |
| Peptide(s) Studied | Vilon |
Key Findings
- Chronic administration of synthetic dipeptide Vilon (L-Lys-L-Glu) inhibited spontaneous tumor growth in SHR mice
- Vilon increased mean lifespan compared to control animals
- The dipeptide showed immunomodulatory activity, supporting thymic function
- Effects were attributed to immune system restoration and anti-tumor immune surveillance enhancement
Study Design
Long-term animal study in female SHR mice (a strain prone to spontaneous tumors). Mice received chronic Vilon administration and were followed for lifespan, tumor incidence, and tumor growth rate compared to untreated controls.
Limitations
- Single mouse strain (SHR), limiting generalizability
- All authors from the Khavinson/Anisimov group
- No independent replication
- Mechanism of anti-tumor action not fully characterized
Clinical Relevance
Provides preclinical evidence for geroprotective and anti-tumor properties of Vilon. However, translation to human use remains speculative without clinical trials.
Methodological Note: This study originates from the Khavinson bioregulation group. Independent replication by Western laboratories is lacking.
Related
#research #animal-in-vivo #evidence-level-V #khavinson-bioregulator #peptide-vilon