Triptorelin

Quick Facts

Full Name: Triptorelin (D-Trp6-GnRH)
Aliases: Triptorelin pamoate, Decapeptyl, Trelstar, Diphereline
Category: Sexual Health / Testosterone Restart / PCT / Hormonal Health
Sequence: pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 (GnRH superagonist; D-Trp substitution at position 6)
Molecular Weight: 1311.5 Da
Administration: Subcutaneous (single injection for PCT)
Typical Dose: 100 mcg single injection (PCT restart); 1–3.75 mg depot (oncology)
Half-Life: ~3 hours (free peptide); depot formulations last weeks–months
Status: FDA-approved (oncology); Research Only for PCT use
WADA Status: Prohibited (S4)

What It Does

Triptorelin is a potent GnRH superagonist used clinically for prostate cancer, endometriosis, and precocious puberty. In PCT (post-cycle therapy) after anabolic steroid or SARMs use, a single subcutaneous injection of 100 mcg triptorelin triggers a powerful LH/FSH surge that can restart the HPG axis. This "GnRH superagonist restart" approach offers a faster, more complete HPTA restoration vs. traditional SERMs alone (Clomid/Nolvadex), though it requires careful management to avoid subsequent axis suppression.

Mechanism of Action

GnRH receptor superagonism: D-Trp6 substitution makes it ~100x more potent than native GnRH and resistant to degradation → massive initial LH/FSH surge (flare effect)
PCT restart mechanism: The initial flare rapidly restores LH → testosterone production in suppressed testes; FSH → spermatogenesis resumption
Continuous use = suppression: Like all GnRH agonists, continuous dosing downregulates GnRH receptors → castrate levels (used in prostate cancer); PCT benefit is from the SINGLE ACUTE FLARE only
HPG axis reset: Single-dose approach allows natural pulsatile GnRH/LH rhythm to resume without subsequent suppression
SERM synergy: Often followed by Clomiphene or Tamoxifen to continue LH support after triptorelin flare

Dosing Protocols

PCT Restart Protocol

Dose: 100 mcg SubQ — single injection ONLY
Timing: 2 weeks after last anabolic steroid dose (or at end of SARMs cycle)
Follow with: Gonadorelin (2x/week) or SERM (Clomiphene, Tamoxifen) for 4–6 weeks
CRITICAL: Do NOT repeat injection — continuous dosing suppresses axis
Source: The Peptides Bible, PCT research literature

Stacks Well With

Oxytocin – well-being and relational health during hormonal restart
Gonadorelin – post-triptorelin maintenance of HPG axis (2x/week pulsatile)
Kisspeptin-10 – upstream HPG support during recovery
BPC-157 – gut and systemic healing support during PCT

Use Cases

PCT (Post-Cycle Therapy — HPG axis restart after AAS or SARMs)
Hypogonadism restart (secondary hypogonadism from exogenous testosterone)
Fertility Restoration (after suppressive therapy)
(Clinical) Prostate Cancer (depot formulation — pharmacological castration)
(Clinical) Endometriosis and Uterine Fibroids
(Clinical) Precocious Puberty

Contraindications & Safety

Repeat dosing for PCT — NEVER repeat; causes axis suppression, not stimulation
Hormone-sensitive cancers — flare effect can initially worsen symptoms before suppression
Cardiovascular risk — androgen deprivation (clinical depot) increases CV risk; not relevant to single-dose PCT
Osteoporosis risk — chronic GnRH agonist therapy reduces bone density; not relevant to single PCT dose
Hypersensitivity — rare anaphylaxis; have epinephrine available first time
Common side effects (single PCT dose): Temporary testosterone surge, then normalization; hot flashes, fatigue in first 1–2 weeks

Storage

Lyophilized: -20°C long-term; 2–8°C for weeks; protect from light
Reconstituted: Use immediately or within 24 hours; single-use
Solvent: Sterile water for injection (preservative-free); single injection

PubMed Research

Research links will be added after PubMed search

Sources

The Peptides Bible – Hormonal health peptides
Peptide Protocols Master Bible – PCT protocols
Peptides Made Easy – Dosing and clinical context

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